Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
نویسندگان
چکیده
منابع مشابه
Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan.
Dietary restriction (DR) is a widely conserved intervention leading to lifespan extension. Despite considerable effort, the mechanisms underlying DR remain poorly understood. In particular, it remains unclear whether DR prolongs life through conserved mechanisms in different species. Here, we show that, in the most common experimental conditions, lifespan extension by DR is abolished by providi...
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Concluding remarks Before swallowing, everything a mammal samples orally will undergo a chemical analysis provided in large part by the gustatory system. What an animal ingests both in the short-term and over a lifetime has undeniable consequences on survival. So critical are taste sensations to the recognition and enjoyment of foods, and the appropriate digestion and utilization of nutrients, ...
متن کاملDietary restriction affects lifespan but not cognitive aging in Drosophila melanogaster.
Dietary restriction extends lifespan in a wide variety of animals, including Drosophila, but its relationship to functional and cognitive aging is unclear. Here, we study the effects of dietary yeast content on fly performance in an aversive learning task (association between odor and mechanical shock). Learning performance declined at old age, but 50-day-old dietary-restricted flies learned as...
متن کامل4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
Dietary restriction (DR) extends lifespan in multiple species. To examine the mechanisms of lifespan extension upon DR, we assayed genome-wide translational changes in Drosophila. A number of nuclear encoded mitochondrial genes, including those in Complex I and IV of the electron transport chain, showed increased ribosomal loading and enhanced overall activity upon DR. We found that various mit...
متن کاملDietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster
Dietary restriction (DR) can result in lifespan-extension and improved function and health during ageing. Although the impact of DR on lifespan and health has been established in a variety of organisms, most DR experiments are carried out on laboratory strains that have often undergone adaptation to laboratory conditions. The effect of DR on animals recently derived from wild populations is rar...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2018
ISSN: 1422-0067
DOI: 10.3390/ijms19123810